Center for Selective C–H Functionalization
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Stereodivergent Intramolecular C(sp3)–H Functionalization of Azavinyl Carbenes: Synthesis of Saturated Heterocycles and ...

Vincent Lindsay Viart, Hélène M.-F. Richmond Sarpong

Published in Journal of the American Chemical Society

A general approach for the formation of five-membered saturated heterocycles by intramolecular C(sp3)–H functionalization is reported. Using N-sulfonyltriazoles as Rh(II) azavinyl carbene equivalents, a wide variety of stereodefined cis-2,3-disubstituted tetrahydrofurans were obtained with good to excellent diastereoselectivity from readily availab...

Asymmetric Synthesis of Diamine Derivatives via Sequential Palladium and Rhodium Catalysis

Trost, Barry M. Malhotra, Sushant Olson, David E. Maruniak, Autumn Justin Du Bois

Published in Journal of the American Chemical Society

The use of a bifunctional nitrogen nucleophile and an allyl carbonate starting material in successive enantioselective palladium- and diastereoselective rhodium-catalyzed reactions enables the rapid assembly of unique amino aziridine products. Further elaboration of these materials affords complex, stereodefined polyamine architectures, thus demons...

Dichotomous Hydrogen Atom Transfer vs Proton-Coupled Electron Transfer During Activation of X–H Bonds (X = C, N, O) by N...

Dandamudi Usharani David C. Lacy Andrew S. Borovik Sason Shaik

Published in Journal of the American Chemical Society

Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C–H Activation of Tethered Arenes

Gui-Juan Cheng Yun-Fang Yang Peng Liu Ping Chen Tian-Yu Sun Gang Li Xinhao Zhang Ken Houk Jin-Quan Yu Yun-Dong Wu ...

Published in Journal of the American Chemical Society

Highly Convergent Total Synthesis of (+)-Lithospermic Acid via a Late-Stage Intermolecular C–H Olefination

Dong-Hui Wang Jin-Quan Yu

Published in Journal of the American Chemical Society

Palladium-Catalyzed Meta-Selective C–H Bond Activation with a Nitrile-Containing Template: Computational Study on Mechan...

Yun-Fang Yang Gui-Juan Cheng Peng Liu Dasheng Leow Tian-Yu Sun Ping Chen Xinhao Zhang Jin-Quan Yu Yun-Dong Wu Ken Houk ...

Published in Journal of the American Chemical Society

Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug D...

Hui-Xiong Dai Antonia F. Stepan Mark S. Plummer Yang-Hui Zhang Jin-Quan Yu

Published in Journal of the American Chemical Society

Key Mechanistic Features of Enantioselective C-H Bond Activation Reactions Catalyzed by [N-Protected Amino Acid-Pd(II)] ...

Djamaladdin G. Musaev Alexey Kaledin Bing-Feng Shi Jin-Quan Yu

Published in Journal of the American Chemical Society

Pd(II)-Catalyzed meta-C–H Olefination, Arylation, and Acetoxylation of Indolines Using a U-Shaped Template

Yang, Guoqiang Petra Lindovska Zhu, Dajian Kim, Justin Wang, Peng Tang, Ri-Yuan Mo Movassaghi Jin-Quan Yu

Published in Journal of the American Chemical Society

meta-C-H olefination, arylation, and acetoxylation of indolines have been developed using nitrile-containing templates. The combination of a monoprotected amino acid ligand and the nitrile template attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-H functionalization of electron-rich indolines that are...

On the Mechanism and Selectivity of the Combined C-H Activation/Cope Rearrangement

Jørn H. Hansen Timothy M. Gregg Stephanie R. Ovalles Yajing Lian Jochen Autschbach Huw M. L. Davies

Published in Journal of the American Chemical Society

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