Decarbonylative organoboron cross-coupling of esters by nickel catalysis
Published in Nature Communications
An expedient synthesis of maraviroc (UK-427,857) via C–H functionalization
Published in Tetrahedron Letters
A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C–H functionalization.
Selective C–C and C–H Bond Activation/Cleavage of Pinene Derivatives: Synthesis of Enantiopure Cyclohexenone Scaffolds a...
Published in Journal of the American Chemical Society
The continued development of transition-metal-mediated C-C bond activation/cleavage methods would provide even more opportunities to implement novel synthetic strategies. We have explored the Rh(I)-catalyzed C-C activation of cyclobutanols resident in hydroxylated derivatives of pinene, which proceed in a complementary manner to the C-C bond cleava...
Using IR vibrations to quantitatively describe and predict site-selectivity in multivariate Rh-catalyzed C-H functionali...
Published in Chemical science
Achieving selective C-H functionalization is a significant challenge that requires discrimination between many similar C-H bonds. Yet, reaction systems employing Rh2(DOSP)4 and Rh2(BPCP)4 were recently demonstrated to afford high levels of selectivity in the C-H insertion of carbenes into toluene-derived substrates. Herein, we explore the origin of...
Stereodivergent Intramolecular C(sp3)–H Functionalization of Azavinyl Carbenes: Synthesis of Saturated Heterocycles and ...
Published in Journal of the American Chemical Society
A general approach for the formation of five-membered saturated heterocycles by intramolecular C(sp3)–H functionalization is reported. Using N-sulfonyltriazoles as Rh(II) azavinyl carbene equivalents, a wide variety of stereodefined cis-2,3-disubstituted tetrahydrofurans were obtained with good to excellent diastereoselectivity from readily availab...
Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation
Published in Nature Communications
Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into protein scaffolds have the potential to impart to chemical reactions selectivity that would be difficult to achieve using metal catalysts alone. In this work, we covalently link an alkyne-substituted dirhodium catalyst to a prolyl oligopeptidase containing a gen...
Rh(III)-catalyzed C–H olefination of N-pentafluoroaryl benzamides using air as the sole oxidant
Published in Advances in Chemical Engineering and Science
Cobalt catalyzed sp3 C–H amination utilizing aryl azides
Published in Advances in Chemical Engineering and Science
Cu(II)-Mediated C(sp2)–H Hydroxylation
Published in Journal of Synthetic Organic Chemistry Japan
Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural pro...
Published in Applied and Environmental Microbiology
